FOR ADULTS AND CHILDREN 12 YEARS OF AGE OR OLDER WHOSE CRC HAS SPREAD TO OTHER PARTS
OF THE BODY (METASTATIC), IS MSI-H OR dMMR, AND HAS PROGRESSED AFTER TREATMENT WITH A
FLUOROPYRIMIDINE, OXALIPLATIN, AND IRINOTECAN
THE OPDIVO® (nivolumab) +
UP TO HELP FIGHT
CRC IN PREVIOUSLY
The study was designed to look at overall response rate (ORR). ORR is the percentage of people who responded to treatment. These people saw their tumors either shrink (partial response) or disappear completely (complete response).
What are the serious side effects of OPDIVO when used in combination with YERVOY?
OPDIVO can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include lung problems (pneumonitis); intestinal problems (colitis) that can lead to tears or holes in your intestine; liver problems (hepatitis); hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas); kidney problems (including nephritis and kidney failure); skin problems; inflammation of the brain (encephalitis); problems in other organs; severe infusion reactions. Additional serious side effects observed during a separate study of YERVOY alone include: nerve problems that can lead to paralysis and eye problems.
What are the most common side effects of OPDIVO when used in combination with YERVOY?
The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; rash; diarrhea; nausea; fever; pain in muscles, bones, and joints; itching; abdominal pain; vomiting; cough; decreased appetite; and shortness of breath.
Keeping your 2-phase treatment in focus
Learn how this treatment schedule helps you complete the combination treatment in 9 weeks,
followed by one monotherapy treatment.
This is a recommended schedule. Discuss any questions you have with your doctor.
Before you receive the OPDIVO + YERVOY combination, tell your healthcare provider if you:
- Have immune system problems such as Crohn's disease, ulcerative colitis, lupus, or sarcoidosis
- Have had an organ transplant
- Have lung or breathing problems
- Have any other medical conditions
- Are pregnant or plan to become pregnant
- - OPDIVO and YERVOY can harm your unborn baby
- - Females who are able to become pregnant should use an effective method of birth control during and for at least 5 months after the last dose of OPDIVO. Talk to your healthcare provider about birth control methods that you can use during this time
- - Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment. You or your healthcare provider should contact Bristol-Myers Squibb at 1-800-721-5072 as soon as you become aware of the pregnancy
- Are breastfeeding or plan to breastfeed
- - It is not known if either treatment passes into your breast milk
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.