For questions about BMS medicines during this time, please call 1-800-721-8909.

Esophageal or gastroesophageal junction (GEJ) cancer that has been treated with chemoradiation followed by surgery to help prevent it from coming back

Your treatment plan at a glance

These are general recommendations about treatment timing and dosing based on a clinical trial. Only your doctor can make specific recommendations about your treatment with OPDIVO.

Here’s a quick look at the treatment schedule—including the flexible option of every 2 weeks or every 4 weeks for a total duration of 1 year.

OPDIVO® (nivolumab) dosing information

OPDIVO is given through an intravenous (IV) infusion. The medicine is given directly into the bloodstream through a vein, usually in the arm or hand, by a healthcare professional.

The infusion takes 30 minutes, though actual time in the clinic may vary.

Your doctor will decide how many treatments are right for you. You may be on treatment for a total duration of 1 year as long as it is working and side effects are tolerable.

Frequent communication with your healthcare team is an important part of treatment. Use your appointment to let them know how you're feeling and ask any questions you may have. You may also be able to talk with others going through a similar situation.

Try to schedule your appointments for the same day of the week to make them easier to remember. It is important to keep all appointments with your healthcare team. If you miss one, call your healthcare team as soon as possible to reschedule your appointment.

A member of your healthcare team will do blood tests to check for side effects during your treatment with OPDIVO and may treat you with a corticosteroid or medicines. OPDIVO treatments may also need to be delayed or completely stopped if you have severe side effects. Be sure to talk to your healthcare team about side effects.

It may be helpful to review a list of questions you might want to ask your doctor. Visit our Patient Resources Page for a list of questions you may want to ask your doctor.

Before you receive OPDIVO, tell your healthcare team about all your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area in the past and have received other medicines that are like OPDIVO
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. OPDIVO can harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if OPDIVO passes into your breast milk. Do not breastfeed during treatment with OPDIVO and for 5 months after the last dose of OPDIVO.

Females who are able to become pregnant:

Your healthcare provider should do a pregnancy test before you start receiving OPDIVO.

  • You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of OPDIVO. Talk to your healthcare provider about birth control methods that you can use during this time.
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with OPDIVO. You or your healthcare provider should contact Bristol Myers Squibb at 1-844-593-7869 as soon as you become aware of a pregnancy.

Tell your healthcare team about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.