Living With This Condition

Getting a cancer diagnosis is a difficult experience. When you first hear about your diagnosis, you may feel anxious, scared, or overwhelmed. You may face a lot of treatment decisions and will have many questions. That’s why it is important to communicate with your healthcare team about any concerns you may have about important areas of your health including nutrition, exercise, and managing stress.

Questions About Diet and Nutrition

During treatment, you may have questions about your diet. Every patient is different and may have different nutritional needs. Here are some questions you can ask your healthcare team regarding your diet and nutrition while you are undergoing treatment:

  • Will there be any adjustments to my diet while undergoing treatment?
  • Will my appetite be affected?
  • What should my diet consist of while I am on treatment?
  • Should I add vitamins and nutritional supplements to my dietary routine?
  • Is it important to drink fluids during my treatment?

Questions About Exercise

Today, many cancer treatment teams may encourage their patients to be as physically active as possible. Here are some questions you can ask your healthcare team regarding exercise. Before starting an exercise routine while you are undergoing treatment, be sure to discuss this with your doctor.

  • Is it safe to exercise during cancer treatment?
  • What type of activity should I do?
  • If I am allowed to weight train, are there any limits to the amount of weight I should use?
  • Are there any restrictions on physical activity?
  • Are there any additional resources available to me?

Questions About Coping With Stress and Emotions During and After Treatment

A cancer diagnosis may have a major impact on patients. During treatment and recovery, people with cancer may feel fearful and anxious. Fear of treatment, doctor visits, and tests might also cause apprehension. It’s important to discuss any changes in your mood with your healthcare team. Here are some questions to ask to help guide that discussion.

To get more ideas to discuss with your doctor about emotional support during and after treatment, click here for a list of resources.

  • If I feel anxious about treatment and tests, who can I talk to?
  • Who can I reach out to for support?
  • What are things I can try to do to help myself If I feel fearful or anxious?
  • Are there any cancer support groups?
  • When should I talk to my healthcare team about changes in my mood?

Building a Support Network

Facing a cancer diagnosis and treatment can be an overwhelming experience. It also affects family and friends. Family
members may be supportive, or they may be worried and afraid. This is an opportunity for you to get support from family
and friends.

Ask for Help—Don’t be embarrassed to ask for help. It’s not a sign of weakness. Your loved ones will want to help. You may also find volunteers through house of worship or community groups. Professional helpers can also be hired to assist with physical care and other needs.

Determine Where You Need Support—You may need help with chores and errands, or you may need someone to take time off work to drive you to treatments. You may need help with daily errands or cooking meals. Find people that can be part of your core support network to help with these tasks.

Be a Team—It’s important that you, your family members, and other people who offer support function as a team. Talk about which decisions you should make together and which decisions you should make alone.

Join a Support Group—There are many resources out there offering help for cancer patients. Support groups are one way to help people with cancer and their loved ones who are affected by the disease. For cancer patients, this is an opportunity to expand their support network by being with others with similar cancer experiences.

Click here for a list of support organizations and online communities to expand your support network.

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SELECT IMPORTANT FACTS ABOUT OPDIVO AND YERVOY

OPDIVO is a medicine that may treat certain cancers by working with your immune system. OPDIVO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when OPDIVO is used in combination with YERVOY.

YERVOY can cause serious side effects in many parts of your body which can lead to death. These problems may happen anytime during treatment with YERVOY or after you have completed treatment.

Important Safety Information
for OPDIVO® (nivolumab) and
the OPDIVO+YERVOY® (ipilimumab) Regimen

OPDIVO is a medicine that may treat certain cancers by working with your immune system. OPDIVO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when OPDIVO is used in combination with YERVOY.

YERVOY can cause serious side effects in many parts of your body which can lead to death. These problems may happen anytime during treatment with YERVOY or after you have completed treatment.

Serious side effects may include:

  • Lung problems (pneumonitis). Symptoms of pneumonitis may include: new or worsening cough; chest pain; and shortness of breath.
  • Intestinal problems (colitis) that can lead to tears or holes in your intestine. Signs and symptoms of colitis may include: diarrhea (loose stools) or more bowel movements than usual; blood in your stools or dark, tarry, sticky stools; and severe stomach area (abdomen) pain or tenderness.
  • Liver problems (hepatitis). Signs and symptoms of hepatitis may include: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); drowsiness; dark urine (tea colored); bleeding or bruising more easily than normal; feeling less hungry than usual; and decreased energy.
  • Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas). Signs and symptoms that your hormone glands are not working properly may include: headaches that will not go away or unusual headaches; extreme tiredness; weight gain or weight loss; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness; hair loss; feeling cold; constipation; voice gets deeper; and excessive thirst or lots of urine.
  • Kidney problems, including nephritis and kidney failure. Signs of kidney problems may include: decrease in the amount of urine; blood in your urine; swelling in your ankles; and loss of appetite.
  • Skin Problems. Signs of these problems may include: rash; itching; skin blistering; and ulcers in the mouth or other mucous membranes.
  • Inflammation of the brain (encephalitis). Signs and symptoms of encephalitis may include: headache; fever; tiredness or weakness; confusion; memory problems; sleepiness; seeing or hearing things that are not really there (hallucinations); seizures; and stiff neck.
  • Problems in other organs. Signs of these problems may include: changes in eyesight; severe or persistent muscle or joint pains; severe muscle weakness; and chest pain.

Additional serious side effects observed during a separate study of YERVOY alone include:

  • Nerve problems that can lead to paralysis. Symptoms of nerve problems may include: unusual weakness of legs, arms, or face; and numbness or tingling in hands or feet.
  • Eye problems. Symptoms may include: blurry vision, double vision, or other vision problems; and eye pain or redness.

Getting medical treatment right away may keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during treatment. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment, if you have severe side effects.

OPDIVO can cause serious side effects, including:

  • Severe infusion reactions. Tell your doctor or nurse right away if you get these symptoms during an infusion of OPDIVO: chills or shaking; itching or rash; flushing; difficulty breathing; dizziness; fever; and feeling like passing out.

Pregnancy and Nursing:

  • Pregnancy Safety Surveillance Study: Females who become pregnant during treatment with YERVOY are encouraged to enroll in a Pregnancy Safety Surveillance Study. The purpose of this study is to collect information about the health of you and your baby. You or your healthcare provider can enroll in the Pregnancy Safety Surveillance Study by calling 1-844-593-7869.
  • Before receiving treatment, tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if either treatment passes into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of YERVOY.

Tell your healthcare provider about:

  • Your health problems or concerns if you: have immune system problems such as autoimmune disease, Crohn’s disease, ulcerative colitis, lupus, or sarcoidosis; have had an organ transplant; have lung or breathing problems; have liver problems; or have any other medical conditions.
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of OPDIVO when used alone include: feeling tired; pain in muscles, bones, and joints; diarrhea; weakness; shortness of breath; decreased appetite; upper respiratory tract infection; headache; rash; itchy skin; nausea; cough; constipation; back pain; fever; and stomach pain.

The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; diarrhea; fever; shortness of breath; itching; decreased appetite; rash; nausea; vomiting; pain in muscles, bones, and joints; and cough. The most common side effects of YERVOY include: tiredness; diarrhea; itching; rash; nausea; vomiting; headache; weight loss; fever; decreased appetite; and difficulty falling or staying asleep.

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call . You may also report side effects to Bristol-Myers Squibb at .


Please see U.S. Full Prescribing Information, including Boxed WARNING regarding immune-mediated side effects, and Medication Guide for YERVOY.

Please see U.S. Full Prescribing Information and Medication Guide for OPDIVO.