What Should I Know About Potential Side Effects?
Some of the side effects of the OPDIVO® + YERVOY® combination may be life-threatening and may need your doctor’s immediate attention. Be sure to tell your doctor about all side effects as soon as possible, including any changes in how you are feeling, so he or she can help
address them right away.
Lung Problems (pneumonitis)
- new or worsening cough
- chest pain
- shortness of breath
Intestinal Problems (colitis) that can lead to tears or holes in your intestine
- diarrhea (loose stools) or more bowel movements than usual
- blood in your stools or dark, tarry, sticky stools
- severe stomach area (abdomen) pain or tenderness
Liver Problems (hepatitis)
- yellowing of your skin or the whites of your eyes
- severe nausea or vomiting
- pain on the right side of your stomach area (abdomen)
- dark urine (tea colored)
- bleeding or bruising more easily than normal
- feeling less hungry than usual
- decreased energy
Hormone Gland Problems (especially the thyroid, pituitary, adrenal glands, and pancreas)
- headaches that will not go away or unusual headaches
- extreme tiredness
- weight gain or weight loss
- dizziness or fainting
- changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness
- hair loss
- feeling cold
- voice gets deeper
- excessive thirst or lots of urine
including nephritis and kidney failure
- decrease in the amount of urine
- blood in your urine
- swelling in your ankles
- loss of appetite
- skin blistering
- ulcers in mouth or other mucous membranes
Inflammation of the
- tiredness or weakness
- memory problems
- seeing or hearing things that are not really there (hallucinations)
- stiff neck
Problems in Other Organs
- changes in eyesight
- severe or persistent muscle or joint pains
- severe muscle weakness
- chest pain
Severe Infusion Reactions
Tell your doctor or nurse right away if you get these symptoms during an infusion of OPDIVO:
- chills or shaking
- itching or rash
- difficulty breathing
- feeling like passing out
REPORTING SIDE EFFECTS EARLY IS IMPORTANT
Combining OPDIVO and YERVOY may increase the chances of side effects. Talking to your healthcare team about how you are feeling can help make them aware of side effects early. Treating side effects early may help keep them from becoming more serious.
It is also important to remember that you are not alone. Everyone’s support network is different, and support can come from many different people.
HOW CAN I PLAY A MORE ACTIVE ROLE IN COMMUNICATION WITH MY HEALTHCARE TEAM?
Your healthcare team will run routine tests to check for some signs of side effects, but tests can
only go so far. It’s important to play an active role, as many of the signs can only be noticed by
you, such as changes in the way you are feeling.
Here are some important things you can do to make your healthcare team aware of side effects as early as possible:
- Pay close attention to how you are feeling, and be especially aware of any new discomfort that appears out of nowhere or any condition that suddenly gets worse.
- If you do notice a change in the way you are feeling—even if it seems small or irrelevant—contact your healthcare team immediately. Do not wait until your next clinic appointment.
- Do not try to treat possible side effects yourself.
HERE ARE SOME STEPS YOU CAN TAKE WITH YOUR BROADER SUPPORT NETWORK
With busy schedules and so many important things to worry about, it can be hard to find time to
reach out to your healthcare team. Here are some tips for communicating with your team:
- Figure out the best way to contact your doctor, and plan ahead
- Report how you are feeling—it is an important thing you can do for your treatment
- Remember that your healthcare team wants to hear about any concerns you are having
- Use resources, like a journal, to help track how you are feeling
HOW CAN MY SUPPORT NETWORK HELP ME PLAY A MORE ACTIVE ROLE?
Not all patients have a caregiver, but those who do may have a helping hand. A caregiver—or
other community member—can help you:
- Monitor and track how you are feeling
- Call your healthcare team
- Ask questions and help remember the answers
- Keep track of appointments and treatment records
Sign up for the OPDIVO with You program for additional support for patients.
- Getting medical treatment right away may keep the problem from becoming more serious
- Do not treat symptoms yourself
- Do not feel embarrassed or worry that you are bothering your oncologist
What are the most common side effects of OPDIVO when used in combination with YERVOY?
The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; rash; diarrhea; nausea; fever; pain in muscles, bones, and joints; upper respiratory tract infection; itching; abdominal pain; vomiting; cough; decreased appetite; and shortness of breath. The most common side effects of YERVOY include: feeling tired; diarrhea; nausea; itching; rash; vomiting; headache; weight loss; fever; decreased appetite; and difficulty falling or staying asleep.
What are the serious side effects of OPDIVO when used in combination with YERVOY?
OPDIVO can cause problems that can sometimes become serious or
- lung problems (pneumonitis)
- intestinal problems (colitis) that can lead to tears or holes in your intestine
- liver problems (hepatitis)
- hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas )
- kidney problems, including nephritis and kidney failure
- skin problems
- inflammation of the brain (encephalitis)
- problems in other organs
- severe infusion reactions
Additional serious side effects observed during a separate study of YERVOY alone include:
- nerve problems that can lead to paralysis
- eye problems
See Clinical Trial Results
See how OPDIVO + YERVOY performed in a
clinical trial in patients.