What Should I Know About Potential Side Effects?
While everyone is different, you may find it helpful to learn what other patients have experienced during treatment with the OPDIVO® + YERVOY® combination. The chart below will give you an idea of what to look out for, in case you have any side effects.
It’s important to remember that this chart does not include all possible side effects of the OPDIVO + YERVOY combination. That’s why you need to report any discomfort or change in the way you are feeling to your healthcare team, even if your symptoms are not listed below. Some of the side effects of the OPDIVO + YERVOY combination may be life-threatening and may need your doctor's immediate attention.
Lung Problems (pneumonitis)
- new or worsening cough
- chest pain
- shortness of breath
Intestinal Problems (colitis) that can lead to tears or holes in your intestine
- diarrhea (loose stools) or more bowel movements than usual
- blood in your stools or dark, tarry, sticky stools
- severe stomach area (abdomen) pain or tenderness
Liver Problems (hepatitis)
- yellowing of your skin or the whites of your eyes
- severe nausea or vomiting
- pain on the right side of your stomach area (abdomen)
- dark urine (tea colored)
- bleeding or bruising more easily than normal
- feeling less hungry than usual
- decreased energy
Hormone Gland Problems (especially the thyroid, pituitary, adrenal glands, and pancreas)
- headaches that will not go away or unusual headaches
- extreme tiredness
- weight gain or weight loss
- dizziness or fainting
- changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness
- hair loss
- feeling cold
- voice gets deeper
- excessive thirst or lots of urine
including nephritis and kidney failure
- decrease in the amount of urine
- blood in your urine
- swelling in your ankles
- loss of appetite
- skin blistering
- ulcers in mouth or other mucous membranes
Inflammation of the
- tiredness or weakness
- memory problems
- seeing or hearing things that are not there (hallucinations)
- stiff neck
Problems in Other Organs
- changes in eyesight
- severe or persistent muscle or joint pains
- severe muscle weakness
- chest pain
Severe Infusion Reactions
Tell your doctor or nurse right away if you get these symptoms during an infusion of OPDIVO:
- chills or shaking
- itching or rash
- difficulty breathing
- feeling like passing out
REPORTING SIDE EFFECTS
EARLY IS IMPORTANT
Combining OPDIVO and YERVOY may increase the chances of side effects. This is why it is especially important to communicate regularly with your team about how you are feeling. Talking to your healthcare team about how you are feeling can help make them aware of side effects early. Treating side effects early may help keep them from becoming more serious.
It is also important to remember that you are not alone. Everyone’s support network is different, and support can come from many different people.
HOW CAN I PLAY A MORE ACTIVE ROLE IN
COMMUNICATION WITH MY HEALTHCARE TEAM?
Your healthcare team will run routine tests to check for some signs of side effects, but tests can only go so far. It’s important to play an active role, as many of the signs can only be noticed by you, such as changes in the way you are feeling.
Here are some important
things you can do to make your healthcare team aware of side
effects as early as possible:
- Pay close attention to how you are feeling, and be especially aware of any new discomfort that appears out of nowhere or any condition that suddenly gets worse.
- If you do notice a change in the way you are feeling—even if it seems small or irrelevant—contact your Oncology Care Team immediately. Do not wait until your next clinic appointment.
- Do not try to treat possible side effects yourself.
TIPS FOR COMMUNICATING
WITH YOUR TEAM
With busy schedules and so many important things to worry about, it can be hard to find time to reach out to your healthcare team. Here are some tips for communicating with your team:
- Figure out the best way to contact your doctor, and plan ahead Talk to your doctor or nurse about the best way to reach them. You might be able to get in touch with a direct call, email, or text.
- Report how you are feeling—it is an important thing you can do for your treatment Frequent communication can help your healthcare team manage side effects right away, which may keep them from becoming more serious.
- Remember that your healthcare team wants to hear about any concern you are having Don't feel like you’re bothering your healthcare team by getting in touch, even if you are not sure that what you are feeling is a side effect. It is best for your oncologist to make that decision.
- Use resources to help track how you are feeling Sometimes it is difficult to remember everything you feel over time, which can make it tough to notice small changes. Using a journal or symptom tracker may help.
HOW CAN MY SUPPORT NETWORK HELP ME PLAY A MORE ACTIVE ROLE?
All of this information may seem overwhelming at first, but it is important to remember that you are not alone. You are part of a team that is working to help you be as healthy as possible.
Your healthcare team
This team includes your oncologist, nurses, and other clinic staff. When it comes to managing health and side effects, they are your most important source of information and support. Their role is to:
- Answer questions about your treatment
- Measure your health and track any changes
- Respond to your calls about possible side effects you experience
- Manage any side effects that you may have
Your broader support network
Not all patients have a caregiver, but those who do may have a helping hand. A caregiver—or other community member—can help you:
- Monitor and track how you are feeling
- Call your healthcare team
- Ask questions and help remember the answers
- Keep track of appointments and treatment records
Advocacy and support groups can help you to meet other patients, share experiences, and access educational resources.
Learn more about how they can help.
- Getting medical treatment right away may keep the problem from becoming more serious
- Do not treat symptoms yourself
- Do not feel embarrassed
or worry that you are bothering your oncologist
What are the most common side effects of OPDIVO when used in combination with YERVOY?
The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; rash; diarrhea; nausea; fever; pain in muscles, bones, and joints; itching; abdominal pain; vomiting; cough; decreased appetite; and shortness of breath.
What are the serious side effects of OPDIVO when used in combination with YERVOY?
OPDIVO can cause problems that
can sometimes become serious or
life-threatening and can lead to death. Serious side effects may include:
- lung problems (pneumonitis)
- intestinal problems (colitis) that can lead to tears or holes in your intestine
- liver problems (hepatitis)
- hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas)
- kidney problems, including nephritis and kidney failure
- skin problems
- inflammation of the brain (encephalitis)
- problems in other organs
- severe infusion reactions
Additional serious side effects observed during a separate study of YERVOY alone include:
- nerve problems that can lead to paralysis
- eye problems
See Clinical Trial Results
See how OPDIVO + YERVOY
performed in a clinical
trial in patients.